LNX1 antibody

Catalog No. ABIN7115860

This Rabbit Polyclonal antibody specifically detects LNX1 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LNX1 antibody (ABIN7115860)

Target: LNX1 (Ligand of Numb-Protein X 1 (LNX1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LNX1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-LNX1 Antibody

Purpose: LNX1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ligand of numb-protein X 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for LNX1

Target: LNX1 (Ligand of Numb-Protein X 1 (LNX1))

Alternative Name: LNX1

Background:

Synonyms: E3 ubiquitin-protein ligase LNX|Ligand of Numb-protein X 1|Numb-binding protein 1|PDZ domain-containing RING finger protein 2|RING-type E3 ubiquitin transferase LNX|LNX1|LNX|PDZRN2

Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65(By similarity). Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

Molecular Weight: 70 kDa

Gene ID: 84708

UniProt: Q8TBB1